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In this study, the rats they chemically-induced amnesia in performed better in a maze after being injected with oxiracetam.2Hlinák Z, Krejcí I. Oxiracetam prevents the MK-801 induced amnesia for the elevated plus-maze in mice Behav Brain Res. 2000
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he authors believe that Oxiracetam favorably acts on the symptoms of senile cerebral deterioration and can improve the capability of information processing.3Rozzini R, Zanetti O, Bianchetti A. Treatment of cognitive impairment secondary to degenerative dementia. Effectiveness of oxiracetam therapy Acta Neurol (Napoli). 1993
They concluded that oxiracetam favourably acts on the symptoms of senile cerebral deterioration and can improve the capability of information processing.8Rozzini R, Zanetti O, Bianchetti A. Effectiveness of oxiracetam therapy in the treatment of cognitive deficiencies secondary to primary degenerative dementia Acta Neurol (Napoli). 1992
One study found that dementia patients taking oxiracetam over 12 weeks performed significantly better on cognition and memory tests than patients taking a placebo.10Bottini G, et al. Oxiracetam in dementia: a double-blind, placebo-controlled study Acta Neurol Scand. 1992
They also have slightly different mechanisms of action. According to clinical research, Piracetam and Oxiracetam have opposing effects on the content of high-energy phosphates and shape of astrocytes in vitro.11Gabryel B, et al. Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro Pol J Pharmacol. 1999
Oxiracetam increases the availability of acetylcholine (ACh) available in the brain by boosting the sensitivity of ACh receptors, such as NMDA and AMPA. It also may be able to repair damaged receptors. This can have a huge impact on learning and memory, especially as you get older.12Fordyce DE, et al. Enhancement of hippocampally-mediated learning and protein kinase C activity by oxiracetam in learning-impaired DBA/2 mice Brain Res. 1995
Oxiracetam can increase protein kinase activity in the hippocampus, which is important for cognitive function and memory encoding.15Gabryel B, et al. Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro Pol J Pharmacol. 1999
Oxiracetam is nootropic agent of the racetam family, a cyclic derivative of γ-aminobutyric acid (GABA) the chief inhibitory neurotransmitter in mammals. It has been shown to improve memory and learning in mouse models. In pharma, it is used as a racemic mixture of (S)-oxiracetam and (R)-oxiracetam, the pharmacological activity is mainly associated with one enantiomer, (S)-oxiracetam. Oxiracetam is slightly soluble in water and DMSO but is practically insoluble in ethanol. 041b061a72